Vardamate 20 Tablet | 10's pack | ePharma
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Vardamate 20 Tablet 10's pack

Generic: Vardenafil

Type: Tablet

Pack Size: 10 Pcs

Vardenafil is used in the treatment of Erectile Dysfunction.


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Discount Price: ৳ 570
MRP: ৳ 600 5% Off

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✅ Description:

Erectile dysfunction (ED) specifically refers to trouble getting or keeping an erection, despite having a healthy sex drive. This issue often has a physical basis and affects about 1 in 5 men, becoming more common with age. At age 40, around 5% of men experience ED, but this rises to 15% by age 70. However, ED can be treated at any age.

ED occurs when blood flow to the penis is restricted, preventing the two chambers (corpora cavernosa) from filling and expanding. This process is initiated by impulses from the brain and genital nerves. Chronic conditions like diabetes, cardiovascular disease, atherosclerosis, kidney disease, and multiple sclerosis can lead to ED by affecting blood flow. Men with diabetes are particularly at risk, being two to three times more likely to develop ED, often 10 to 15 years earlier than men without diabetes. Proper blood sugar control can mitigate this risk.

Lab tests, including blood cell counts, blood sugar levels, cholesterol levels, and liver tests, can help diagnose ED by revealing underlying medical conditions.

Safety Advices


Alcohol
UNSAFE

Avoid consumption of alcohol while taking Vardamate 20 Tablet as it may worsen erection dysfunction.


Pregnancy
UNSAFE

Vardamate 20 Tablet is not recommended for use by pregnant women as the medicine is intended to be used only in men.


Breastfeeding
UNSAFE

Vardamate 20 Tablet is not recommended for use breastfeeding women as the medicine is intended to be used only in men.


Driving
UNSAFE

Do not drive or operate any machines if you feel dizzy or your vision is affected after taking Vardamate 20 Tablet.


Kidney
CONSULT YOUR DOCTOR

Vardamate 20 Tablet is not recommended for use in patients undergoing kidney dialysis. Consult your doctor before taking Vardamate 20 Tablet.


Liver
CONSULT YOUR DOCTOR

Vardamate 20 Tablet is not recommended for use in patients suffering from severe liver disease. Consult your doctor before taking Vardamate 20 Tablet.

Similar Products

✔️ Uses of Vardamate 20 Tablet

Treatment of Erectile Dysfunction.

✔️ How does Vardamate 20 Tablet work?

Vardenafil is a phosphodiesterase (PDE-5) inhibitor. It works in erectile dysfunction by increasing blood flow to the penis by relaxing the muscles in penile blood vessels. It helps to get an erection only if the person is sexually stimulated.

✔️ Side Effects of Vardamate 20 Tablet

Headache, Flushing (sense of warmth in the face, ears, neck, and trunk), Dizziness, Back pain, Nausea, Nasal congestion (stuffy nose), Dyspepsia, Sinus inflammation, Flu-like symptoms, Increased creatine level in blood

✔️ Quick Suggestions:
  • Vardenafil enhances erectile function by increasing cGMP levels in response to sexual stimulation.
  • The medication is effective only with sexual stimulation, as this initiates the nitric oxide release necessary for the cGMP pathway.
  • The specificity of vardenafil for PDE5 ensures targeted action on erectile function with minimal effects on other phosphodiesterase.
  • Exercise and maintain a healthy weight.
  • Stop smoking.
  • Avoid alcohol and substance abuse.
  • Keep diabetes under control.
✔️ Indications:

Vardenafil works by blocking the effects of certain enzymes (PDE5) which limits blood flow to the penis.

✔️ Pharmacology
  • Selective PDE5 Inhibition: Vardenafil is a selective phosphodiesterase type 5 (PDE5) inhibitor, which specifically targets cyclic guanosine monophosphate (cGMP).
  • Erection Mechanism: Penile erection is a hemodynamic process initiated by the relaxation of smooth muscles in the corpus cavernosum and its arterioles.
  • Nitric Oxide and cGMP Synthesis: During sexual arousal, nitric oxide is released in the corpus cavernosum, activating guanylate cyclase and increasing cGMP synthesis in smooth muscle cells.
  • Smooth Muscle Relaxation: Increased cGMP leads to the relaxation of smooth muscles, allowing more blood flow into the penis, resulting in an erection.
  • Role of PDE5 Inhibition: By inhibiting PDE5, vardenafil increases cGMP levels, thereby improving erectile function. However, sexual stimulation is necessary for the local release of nitric oxide, meaning PDE5 inhibition alone does not induce an erection without sexual arousal.
✔️ Dosage & Administration:

Recommended Starting Dose:

  • Standard Dose: 10 mg once daily, taken orally about 60 minutes before sexual activity.
  • Dose Adjustment: The dose can be increased to a maximum of 20 mg or decreased to 5 mg based on efficacy and side effects.
  • Frequency: Maximum recommended dosing frequency is once per day.
  • Food: Vardenafil can be taken with or without food.

Special Populations:

Geriatrics:

  • Starting Dose: 5 mg should be considered for patients >65 years of age.

Renal Impairment:

  • Dose Adjustment: No dose adjustment is required for patients with renal impairment.

Hepatic Impairment:

  • Moderate Hepatic Impairment:
    • Starting Dose: 5 mg is recommended.
    • Maximum Dose: Should not exceed 10 mg.
  • Severe Hepatic Impairment:
    • Use: Vardenafil should not be used in patients with severe hepatic impairment.
✔️ Interaction

Antihypertensive Drugs:

  • Effect: Vardenafil may enhance the antihypertensive effects of these drugs.
  • Clinical Studies: A single dose of vardenafil 20 mg reduced blood pressure by an average of 7 mmHg systolic and 8 mmHg diastolic.
  • Caution: Advised when co-administered with other vasodilators, including alpha-blockers.

CYP3A4 Inhibitors:

  • Examples: Ketoconazole, indinavir, ritonavir, and erythromycin.
  • Effect: These inhibitors may decrease the excretion of vardenafil from the body, potentially increasing its effects and side effects.
✔️ Contraindications
  • Vardenafil can potentiate the hypotensive effect of nitrates.
  • Contraindicated with regular or intermittent nitrates and nitric oxide donors.
  • Contraindicated in patients with hypersensitivity to vardenafil or any of its ingredients.
✔️ Pregnancy & Lactation

Vardenafil is not indicated for women.

✔️ Precautions & Warnings

Physicians should consider the cardiovascular status of their patients, as there is a certain degree of cardiac risk associated with sexual activity. In men who are discouraged from being sexually active due to their underlying cardiovascular condition, vardenafil should generally not be used.

✔️ Storage Conditions:


Store at room temperature and protect from light and moisture. Keep out of the reach of children.

Frequently Asked Questions (FAQ)

A: Alternatives include alprostadil self-injection, alprostadil urethral suppository, testosterone replacement therapy, penis pumps, and penile implants.

A: Regular exercise, particularly moderate to vigorous aerobic activity, can improve erectile dysfunction. Even less strenuous, regular exercise can reduce the risk of erectile dysfunction.

A: Counseling might be recommended if erectile dysfunction is caused by stress, anxiety, or depression, or if the condition is causing stress and relationship tension. A psychologist or counselor can help address these issues.

A: Vardenafil may enhance the antihypertensive effects of certain drugs, and its excretion can be decreased by CYP3A4 inhibitors like ketoconazole, indinavir, ritonavir, and erythromycin. It should not be used with nitrates due to the risk of severe hypotension.

A: Yes, for patients over 65 years of age, a starting dose of 5 mg should be considered.

A: Yes, Vardenafil can be taken with or without food.

A: The recommended starting dose of Vardenafil is 10 mg taken orally approximately 60 minutes before sexual activity. The dose can be adjusted based on efficacy and side effects, with a maximum dose of 20 mg and a minimum dose of 5 mg.

A: A physical exam, including examination of the penis and testicles, blood tests to check for heart disease, diabetes, and low testosterone levels, urine tests for diabetes and other conditions, ultrasound to assess blood flow problems, and a psychological exam to screen for depression and other psychological causes.
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Check our pricing section for Vardamate 20 Tablet 10's pack price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
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